ARPA-H seeks proposals to develop a revolutionary new cybersecurity platform to enable hospitals and health systems to protect themselves from cyberattacks. The Universal PatchinG and Remediation for Autonomous DEfense (UPGRADE) program will empower hospital information Technology (IT) teams to protect health systems from cyberattacks and ensure continuity of patient care without requiring additional personnel or manual effort. UPGRADE aims to fund the creation of vulnerability mitigation tools that act as a force multiplier for hospital IT/cybersecurity teams, dramatically advancing hospitals’ capacities to understand, source, plan, and deploy security upgrades for connected hospital equipment (e.g., equipment germane to hospital environments including but not limited to infusion pumps, patient monitoring equipment, and imaging equipment). See the attached draft Module Announcement, ARPA-H-MAI-24-01-05 for details on the UPGRADE program.